Stephen Malina

This is my blog. There are many others like it but this one is mine.


Biologizing the stack

I’m experimenting with writing some shorter, less polished posts. These come with the disclaimer that I’m optimizing for getting …

Continuous glucose monitors (CGM) and beyond: A dialogue

What are continuous glucose monitors good for? More broadly, what are continuous measures of physiology (CxM) good for? Similar to Elliot …

What are the bottlenecks to safe, repeatable edits in humans? Part 1

Summary # Gene editing has made a lot of progress over the past few decades. CRISPR-Cas9 sparked the recent fervor and won some of its early …

Dialogue on Viriditas

Introduction # A few months ago, Elliot Hershberg, one of my favorite Substack writers, wrote a post laying out his personal mission. I …

Reflections on 2022

2022 was another exciting, fun year. To round it out, I wrote up some scattered reflections. Enjoy, or if you aren’t a fan of this …

Decentralization of Atoms is Underrated

This post was co-authored with Austin Vernon. Summary # While the internet often focuses its furious debate energy on decentralization in …

GPT4 Predictions

As a way to keep myself honest, I’m going to be recording GPT4 predictions here and archiving versions of the post so I can’t go …

AI Omens: Signs of AI acceleration

A friend recently asked me what my “AI timelines” were. Especially with recent progress in image generation, language modeling, …

Movie Review - Top Gun: Maverick

Since I’ve been going around telling everyone how Top Gun: Maverick (TG:M) is one of the best action movies of our generation, …

Book Review - Elmer Gates and the Art of Mind-using

Introduction # Generally when someone tells you they’ve invented an “art of mind-using” that involves lots of made-up …


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