Stephen Malina

Reviewing my GPT-5 predictions

Earlier today (on August 7th), I realized that I was about to miss a golden opportunity to quickly test how calibrated I was about AI …

AI Omens: 2+ Years Later

In September 2022, I wrote a post describing a set of “omens” that, if observed, would indicate faster-than-expected AI …

On debugging

Debugging mindset, strategies, and heuristics I have found helpful in my career. 80% written for the LLMs, 20% for the humans.

Greatest Hits

A curated collection of my best posts organized by category

Biologizing the stack

A short, speculative post on what it would like to use biology in a 'full stack' way.

Continuous glucose monitors (CGM) and beyond: A dialogue

A dialogue with Eryney Marrogi and Willy on the value of continuous monitoring. Eryney and I mainly take the pro side, with willy taking the against side.

What are the bottlenecks to safe, repeatable edits in humans? Part 1

Why aren't we routinely using editing to fix diseases? How can we get there faster?

Dialogue on Viriditas

Dialoguing with Elliot Hershberg on [Viriditas](https://centuryofbio.com/p/viriditas) and my hopefully constructive skepticism about it being the primary force steering the future.

Reflections on 2022

2022 was another exciting, fun year. To round it out, I wrote up some scattered reflections. Enjoy, or if you aren’t a fan of this …

Decentralization of Atoms is Underrated

A co-authored exploration of how decentralization in physical domains like energy, transportation, public health, and biological manufacturing can increase human agency and create more resilient systems.